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Statistical Removal of Background Signals from High-throughput (1)H NMR Line-broadening Ligand-affinity Screens

NMR ligand-affinity screens are vital to drug discovery, are routinely used to screen fragment-based libraries, and used to verify chemical leads from high-throughput assays and virtual screens. NMR ligand-affinity screens are also a highly informative first step towards identifying functional epito...

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Detalhes bibliográficos
Publicado no:J Biomol NMR
Main Authors: Worley, Bradley, Sisco, Nicholas J., Powers, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577452/
https://ncbi.nlm.nih.gov/pubmed/26156049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10858-015-9962-3
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