PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model

The 12 kDa FK506-binding protein (FK506BP12), an immunosuppressor, modulates T cell activation via calcineurin inhibition. In this study, we investigated the ability of PEP-1-FK506BP12, consisting of FK506BP12 fused to the protein transduction domain PEP-1 peptide, to suppress catabolic responses in...

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Vydáno v:BMB Rep
Hlavní autoři: Hwang, Hyun Sook, Park, In Young, Kim, Dae Won, Choi, Soo Young, Jung, Young Ok, Kim, Hyun Ah
Médium: Artigo
Jazyk:Inglês
Vydáno: Korean Society for Biochemistry and Molecular Biology 2015
Témata:
Research-Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577291/
https://ncbi.nlm.nih.gov/pubmed/25887750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2015.48.7.050
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