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Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising
The past decade has seen the discovery of numerous broad and potent monoclonal antibodies against HIV type 1 (HIV-1). Eliciting these antibodies via vaccination appears to be remarkably difficult, not least because they arise late in infection and are highly mutated relative to germline antibody seq...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577154/ https://ncbi.nlm.nih.gov/pubmed/26324897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505207112 |
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