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Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising

The past decade has seen the discovery of numerous broad and potent monoclonal antibodies against HIV type 1 (HIV-1). Eliciting these antibodies via vaccination appears to be remarkably difficult, not least because they arise late in infection and are highly mutated relative to germline antibody seq...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Luo, Shishi, Perelson, Alan S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577154/
https://ncbi.nlm.nih.gov/pubmed/26324897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505207112
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