An OMV Vaccine Derived from a Capsular Group B Meningococcus with Constitutive FetA Expression: Preclinical Evaluation of Immunogenicity and Toxicity

Following the introduction of effective protein-polysaccharide conjugate vaccines against capsular group C meningococcal disease in Europe, meningococci of capsular group B remain a major cause of death and can result in debilitating sequelae. The outer membrane proteins PorA and FetA have previousl...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Norheim, Gunnstein, Sanders, Holly, Mellesdal, Jardar W., Sundfør, Idunn, Chan, Hannah, Brehony, Carina, Vipond, Caroline, Dold, Chris, Care, Rory, Saleem, Muhammad, Maiden, Martin C. J., Derrick, Jeremy P., Feavers, Ian, Pollard, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577077/
https://ncbi.nlm.nih.gov/pubmed/26390123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134353
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