High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons

The mechanisms by which dietary salt promotes hypertension are unknown. Previous work established that plasma [Na(+)] and osmolality rise in proportion with salt intake and thus promote release of vasopressin (VP) from the neurohypophysis. Although high levels of circulating VP can increase blood pr...

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Publicado en:Neuron
Autores principales: Choe, Katrina Y., Han, Su Y., Gaub, Perrine, Shell, Brent, Voisin, Daniel L., Knapp, Blayne A., Barker, Philip A., Brown, Colin H., Cunningham, J. Thomas, Bourque, Charles W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577058/
https://ncbi.nlm.nih.gov/pubmed/25619659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.12.048
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