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Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis
BNip3 is a hypoxia-inducible protein that targets mitochondria for autophagosomal degradation. We report a novel tumor suppressor role for BNip3 in a clinically relevant mouse model of mammary tumorigenesis. BNip3 delays primary mammary tumor growth and progression by preventing the accumulation of...
में बचाया:
| में प्रकाशित: | EMBO Rep |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
John Wiley & Sons, Ltd
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4576983/ https://ncbi.nlm.nih.gov/pubmed/26232272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540759 |
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