Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

BNip3 is a hypoxia-inducible protein that targets mitochondria for autophagosomal degradation. We report a novel tumor suppressor role for BNip3 in a clinically relevant mouse model of mammary tumorigenesis. BNip3 delays primary mammary tumor growth and progression by preventing the accumulation of...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Chourasia, Aparajita H, Tracy, Kristin, Frankenberger, Casey, Boland, Michelle L, Sharifi, Marina N, Drake, Lauren E, Sachleben, Joseph R, Asara, John M, Locasale, Jason W, Karczmar, Gregory S, Macleod, Kay F
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576983/
https://ncbi.nlm.nih.gov/pubmed/26232272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201540759
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