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Fitness Trade-Offs Determine the Role of the Molecular Chaperonin GroEL in Buffering Mutations

Molecular chaperones fold many proteins and their mutated versions in a cell and can sometimes buffer the phenotypic effect of mutations that affect protein folding. Unanswered questions about this buffering include the nature of its mechanism, its influence on the genetic variation of a population,...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Sabater-Muñoz, Beatriz, Prats-Escriche, Maria, Montagud-Martínez, Roser, López-Cerdán, Adolfo, Toft, Christina, Aguilar-Rodríguez, José, Wagner, Andreas, Fares, Mario A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576708/
https://ncbi.nlm.nih.gov/pubmed/26116858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msv144
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