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Protein Kinase C (PKC)ζ Pseudosubstrate Inhibitor Peptide Promiscuously Binds PKC Family Isoforms and Disrupts Conventional PKC Targeting and Translocation

PKMζ is generated via an alternative transcriptional start site in the atypical protein kinase C (PKC)ζ isoform, which removes N-terminal regulatory elements, including the inhibitory pseudosubstrate domain, consequently rendering the kinase constitutively active. Persistent PKMζ activity has been p...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Bogard, Amy S., Tavalin, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576679/
https://ncbi.nlm.nih.gov/pubmed/26199377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.099457
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