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4-hydroxy-2, 3-nonenal activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells

AIM: Activated pancreatic stellate cells (PSCs) are implicated in the pathogenesis of pancreatic inflammation and fibrosis, where oxidative stress is thought to play a key role. 4-hydroxy-2,3-nonenal (HNE) is generated endogenously during the process of lipid peroxidation, and has been accepted as a...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Kikuta, Kazuhiro, Masamune, Atsushi, Satoh, Masahiro, Suzuki, Noriaki, Shimosegawa, Tooru
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576286/
https://ncbi.nlm.nih.gov/pubmed/15285017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v10.i16.2344
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