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Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions

Current treatments for cutaneous and visceral leishmaniasis are toxic, expensive, difficult to administer, and limited in efficacy and availability. Disulfiram has primarily been used to treat alcoholism. More recently, it has shown some efficacy as therapy against protozoan pathogens and certain ca...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Peniche, Alex G., Renslo, Adam R., Melby, Peter C., Travi, Bruno L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576107/
https://ncbi.nlm.nih.gov/pubmed/26239994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05131-14
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