Down-Regulation of Growth Signaling Pathways Linked to a Reduced Cotyledonary Vascularity in Placentomes of Over-Nourished, Obese Pregnant Ewes

Both protein kinase B (Akt) and extracellular signal-regulated kinase 1/2 (ERK1/2) are down-stream components of the insulin/insulin like growth factor-1 (IGF-1) signaling pathway. AMP-activated protein kinase (AMPK) is known to sensitize cells to insulin/IGF-1 signaling. The objective of this study...

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Publicado en:Placenta
Autores principales: Zhu, M.J., Du, M., Nijland, M.J., Nathanielsz, P.W., Hess, B.W., Moss, G.E., Ford, S.P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575950/
https://ncbi.nlm.nih.gov/pubmed/19268361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.placenta.2009.02.001
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