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The Busulfan Metabolite EdAG Irreversibly Glutathionylates Glutaredoxins
The DNA alkylating agent busulfan is used to ‘precondition’ patients with leukemia, lymphomas and other hematological disorders prior to hematopoietic stem cell transplants. Busulfan is metabolized via conjugation with glutathione (GSH) followed by intramolecular rearrangement to the GSH analog γ–gl...
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| Publicado no: | Arch Biochem Biophys |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575911/ https://ncbi.nlm.nih.gov/pubmed/26278353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2015.08.005 |
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