Gene Therapy Fully Restores Vision to the All-Cone Nrl(−/−)Gucy2e(−/−) Mouse Model of Leber Congenital Amaurosis-1

Mutations in GUCY2D are the cause of Leber congenital amaurosis type 1 (LCA1). GUCY2D encodes retinal guanylate cyclase-1 (retGC1), a protein expressed exclusively in outer segments of photoreceptors and essential for timely recovery from photoexcitation. Recent clinical data show that, despite a hi...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Hum Gene Ther
Glavni autori: Boye, Sanford L., Peterson, James J., Choudhury, Shreyasi, Min, Seok Hong, Ruan, Qing, McCullough, K. Tyler, Zhang, Zhonghong, Olshevskaya, Elena V., Peshenko, Igor V., Hauswirth, William W., Ding, Xi-Qin, Dizhoor, Alexander M., Boye, Shannon E.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2015
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575531/
https://ncbi.nlm.nih.gov/pubmed/26247368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2015.053
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items