Cardiac Safety of TGF-β Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study

Transforming growth factor-beta (TGF-β) signaling plays an important role in the fetal development of cardiovascular organs and in the repair mechanisms of the heart. Hence, inhibitors of the TGF-β signaling pathway require a careful identification of a safe therapeutic window and a comprehensive mo...

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Dettagli Bibliografici
Pubblicato in:Cardiovasc Toxicol
Autori principali: Kovacs, Richard J., Maldonado, Giuliana, Azaro, Analia, Fernández, Maria S., Romero, Federico L., Sepulveda-Sánchez, Juan M., Corretti, Mary, Carducci, Michael, Dolan, Melda, Gueorguieva, Ivelina, Cleverly, Ann L., Pillay, N. Sokalingum, Baselga, Jose, Lahn, Michael M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575352/
https://ncbi.nlm.nih.gov/pubmed/25488804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12012-014-9297-4
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