Genetic Variations in the TP53 Pathway in Native Americans Strongly Suggest Adaptation to the High Altitudes of the Andes

The diversity of the five single nucleotide polymorphisms located in genes of the TP53 pathway (TP53, rs1042522; MDM2, rs2279744; MDM4, rs1563828; USP7, rs1529916; and LIF, rs929271) were studied in a total of 282 individuals belonging to Quechua, Aymara, Chivay, Cabanaconde, Yanke, Taquile, Amantan...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jacovas, Vanessa Cristina, Rovaris, Diego Luiz, Peréz, Orlando, de Azevedo, Soledad, Macedo, Gabriel Souza, Sandoval, José Raul, Salazar-Granara, Alberto, Villena, Mercedes, Dugoujon, Jean-Michel, Bisso-Machado, Rafael, Petzl-Erler, Maria Luiza, Salzano, Francisco Mauro, Ashton-Prolla, Patricia, Ramallo, Virginia, Bortolini, Maria Cátira
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575214/
https://ncbi.nlm.nih.gov/pubmed/26382048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137823
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