Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa

Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in COL7A1 resulting in reduced or absent type VII collagen, aberrant anchoring fibril formation and subsequent dermal-epidermal fragility. Here, we identify a significant decrease in PLOD3 expression and its encoded protein, th...

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Vydáno v:PLoS One
Hlavní autoři: Watt, Stephen A., Dayal, Jasbani H. S., Wright, Sheila, Riddle, Megan, Pourreyron, Celine, McMillan, James R., Kimble, Roy M., Prisco, Marco, Gartner, Ulrike, Warbrick, Emma, McLean, W. H. Irwin, Leigh, Irene M., McGrath, John A., Salas-Alanis, Julio C., Tolar, Jakub, South, Andrew P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575209/
https://ncbi.nlm.nih.gov/pubmed/26380979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137639
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