Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence

Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on genome-wide mRNA and microRNA (miRNA) expression in Nucleus Accumbens (NAc) of subjects with alcohol dependence (AD; N = 18) and of matched controls...

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Udgivet i:PLoS One
Main Authors: Mamdani, Mohammed, Williamson, Vernell, McMichael, Gowon O., Blevins, Tana, Aliev, Fazil, Adkins, Amy, Hack, Laura, Bigdeli, Tim, D. van der Vaart, Andrew, Web, Bradley Todd, Bacanu, Silviu-Alin, Kalsi, Gursharan, Kendler, Kenneth S., Miles, Michael F., Dick, Danielle, Riley, Brien P., Dumur, Catherine, Vladimirov, Vladimir I.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575063/
https://ncbi.nlm.nih.gov/pubmed/26381263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137671
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