Exendin-4 Prevents Vascular Smooth Muscle Cell Proliferation and Migration by Angiotensin II via the Inhibition of ERK1/2 and JNK Signaling Pathways

Angiotensin II (Ang II) is a main pathophysiological culprit peptide for hypertension and atherosclerosis by causing vascular smooth muscle cell (VSMC) proliferation and migration. Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, is currently used for the treatment of type-2 diabetes,...

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Foilsithe in:PLoS One
Main Authors: Nagayama, Kosuke, Kyotani, Yoji, Zhao, Jing, Ito, Satoyasu, Ozawa, Kentaro, Bolstad, Francesco A., Yoshizumi, Masanori
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574935/
https://ncbi.nlm.nih.gov/pubmed/26379274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137960
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