Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma

BACKGROUND: Constitutive MET signaling promotes invasiveness in most primary and recurrent GBM. However, deployment of available MET-targeting agents is confounded by lack of effective biomarkers for selecting suitable patients for treatment. Because endogenous HGF overexpression often causes autocr...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Johnson, Jennifer, Ascierto, Maria Libera, Mittal, Sandeep, Newsome, David, Kang, Liang, Briggs, Michael, Tanner, Kirk, Marincola, Francesco M., Berens, Michael E., Vande Woude, George F., Xie, Qian
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574608/
https://ncbi.nlm.nih.gov/pubmed/26381735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-015-0667-x
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