IL-12p40 Homodimer Ameliorates Experimental Autoimmune Arthritis

IL-23 is the key cytokine that induces the expansion of Th17 cells. It is composed of p19 and p40 subunits of IL-12. The p40 subunit binds competitively to the receptor of IL-23 and blocks its activity. Our aim was to assess the preventive and therapeutic effect of the IL-12p40 homodimer (p40)(2) su...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Lee, Seon-Yeong, Jung, Young Ok, Kim, Doo-Jin, Kang, Chang-Min, Moon, Young-Mee, Heo, Yu-Jung, Oh, Hye-Jwa, Park, Seong-Jeong, Yang, Se-Hwan, Kwok, Seung Ki, Ju, Ji-Hyeon, Park, Sung-Hwan, Sung, Young Chul, Kim, Ho-Youn, Cho, Mi-La
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2015
Assuntos:
Autoimmunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574520/
https://ncbi.nlm.nih.gov/pubmed/26324771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500400
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