Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression

We recently identified Smads1, 5 and 8 as muscle biomarkers in human ALS. In the ALS mouse, these markers are elevated and track disease progression. Smads are signal transducers and become activated upon receptor engagement of ligands from the TGF-β superfamily. Here, we sought to characterize liga...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Si, Ying, Kim, Soojin, Cui, Xiangqin, Zheng, Lei, Oh, Shin J., Anderson, Tina, AlSharabati, Mohammad, Kazamel, Mohamed, Volpicelli-Daley, Laura, Bamman, Marcas M., Yu, Shaohua, King, Peter H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574401/
https://ncbi.nlm.nih.gov/pubmed/26375954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138425
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