Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation

RhoA GTPase has been shown in vitro in cell lines and in vivo in nonmammalian organisms to regulate cell division, particularly during cytokinesis and abscission, when 2 daughter cells partition through coordinated actomyosin and microtubule machineries. To investigate the role of this GTPase in the...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Konstantinidis, Diamantis G., Giger, Katie M., Risinger, Mary, Pushkaran, Suvarnamala, Zhou, Ping, Dexheimer, Phillip, Yerneni, Satwica, Andreassen, Paul, Klingmüller, Ursula, Palis, James, Zheng, Yi, Kalfa, Theodosia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573870/
https://ncbi.nlm.nih.gov/pubmed/26228485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-616169
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