Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, and the key question remains as to how differentiation in tumor cells can...

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Bibliografiska uppgifter
I publikationen:Genes Dev
Huvudupphovsmän: Váraljai, Renáta, Islam, Abul B.M.M.K., Beshiri, Michael L., Rehman, Jalees, Lopez-Bigas, Nuria, Benevolenskaya, Elizaveta V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2015
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573855/
https://ncbi.nlm.nih.gov/pubmed/26314709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.264036.115
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