Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells

The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, and the key question remains as to how differentiation in tumor cells can...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Váraljai, Renáta, Islam, Abul B.M.M.K., Beshiri, Michael L., Rehman, Jalees, Lopez-Bigas, Nuria, Benevolenskaya, Elizaveta V.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2015
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573855/
https://ncbi.nlm.nih.gov/pubmed/26314709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.264036.115
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