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Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells
The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, and the key question remains as to how differentiation in tumor cells can...
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| Publicado en: | Genes Dev |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4573855/ https://ncbi.nlm.nih.gov/pubmed/26314709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.264036.115 |
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