PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis

Sepsis severity has been positively correlated with platelet dysfunction, which may be due to elevations in nitric oxide (NO) and cGMP levels. Protein kinase C, Src kinases, PI3K and AKT modulate platelet activity in physiological conditions, but no studies evaluated the role of these enzymes in pla...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lopes-Pires, M. Elisa, Naime, Ana C. Antunes, Almeida Cardelli, Nádia J., Anjos, Débora J., Antunes, Edson, Marcondes, Sisi
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573322/
https://ncbi.nlm.nih.gov/pubmed/26375024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137901
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