PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis

Sepsis severity has been positively correlated with platelet dysfunction, which may be due to elevations in nitric oxide (NO) and cGMP levels. Protein kinase C, Src kinases, PI3K and AKT modulate platelet activity in physiological conditions, but no studies evaluated the role of these enzymes in pla...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Lopes-Pires, M. Elisa, Naime, Ana C. Antunes, Almeida Cardelli, Nádia J., Anjos, Débora J., Antunes, Edson, Marcondes, Sisi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573322/
https://ncbi.nlm.nih.gov/pubmed/26375024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137901
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