A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity

Increasing evidence indicates that metabolism is implicated in the control of stem cell identity. Here, we demonstrate that embryonic stem cell (ESC) behaviour relies on a feedback loop that involves the non-essential amino acid L-Proline (L-Pro) in the modulation of the Gcn2-Eif2α-Atf4 amino acid s...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: D'Aniello, C, Fico, A, Casalino, L, Guardiola, O, Di Napoli, G, Cermola, F, De Cesare, D, Tatè, R, Cobellis, G, Patriarca, E J, Minchiotti, G
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572871/
https://ncbi.nlm.nih.gov/pubmed/25857264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.24
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