First effects of rising amyloid-β in transgenic mouse brain: synaptic transmission and gene expression

Detecting and treating Alzheimer’s disease, before cognitive deficits occur, has become the health challenge of our time. The earliest known event in Alzheimer’s disease is rising amyloid-β. Previous studies have suggested that effects on synaptic transmission may precede plaque deposition. Here we...

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Vydáno v:Brain
Hlavní autoři: Cummings, Damian M., Liu, Wenfei, Portelius, Erik, Bayram, Sevinç, Yasvoina, Marina, Ho, Sui-Hin, Smits, Hélène, Ali, Shabinah S., Steinberg, Rivka, Pegasiou, Chrysia-Maria, James, Owain T., Matarin, Mar, Richardson, Jill C., Zetterberg, Henrik, Blennow, Kaj, Hardy, John A., Salih, Dervis A., Edwards, Frances A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572488/
https://ncbi.nlm.nih.gov/pubmed/25981962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awv127
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