Reversal of 5-flouroucial resistance by adenovirus-mediated transfer of wild-type p53 gene in multidrug-resiatant human colon carcinoma LoVo/5-FU cells

AIM: To observe the reversal effects of wide-type p53 gene on multi-drug resistance to 5-FU (LOVO/5-FU). METHODS: After treatment with Ad-p53, LOVO/5-FU sensitivity to 5-Fu was investigated using tetrazolium dye assay. Multidrug resistance gene-1 (MDR1) gene expression was assayed by semi-quantitati...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Yu, Zhi-Wei, Zhao, Peng, Liu, Ming, Dong, Xin-Shu, Tao, Ji, Yao, Xue-Qin, Yin, Xin-Hua, Li, Yu, Fu, Song-Bin
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2004
Subjects:
Brief Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572245/
https://ncbi.nlm.nih.gov/pubmed/15222051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v10.i13.1979
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