A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation

The IL-4-inducing principle from Schistosoma mansoni eggs (IPSE/α-1), the major secretory product of eggs from the parasitic worm S. mansoni, efficiently triggers basophils to release the immunomodulatory key cytokine interleukin-4. Activation by IPSE/α-1 requires the presence of IgE on the basophil...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Meyer, N. Helge, Mayerhofer, Hubert, Tripsianes, Konstantinos, Blindow, Silke, Barths, Daniela, Mewes, Astrid, Weimar, Thomas, Köhli, Thies, Bade, Steffen, Madl, Tobias, Frey, Andreas, Haas, Helmut, Mueller-Dieckmann, Jochen, Sattler, Michael, Schramm, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571962/
https://ncbi.nlm.nih.gov/pubmed/26163514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675066
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