Accumulation of Mitochondrial DNA Mutations Disrupts Cardiac Progenitor Cell Function and Reduces Survival

Transfer of cardiac progenitor cells (CPCs) improves cardiac function in heart failure patients. However, CPC function is reduced with age, limiting their regenerative potential. Aging is associated with numerous changes in cells including accumulation of mitochondrial DNA (mtDNA) mutations, but it...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Orogo, Amabel M., Gonzalez, Eileen R., Kubli, Dieter A., Baptista, Igor L., Ong, Sang-Bing, Prolla, Tomas A., Sussman, Mark A., Murphy, Anne N., Gustafsson, Åsa B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2015
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571958/
https://ncbi.nlm.nih.gov/pubmed/26183775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.649657
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