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Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G(1) to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21(Cip1/Waf1)
Nucleolar GTP-binding protein (NGP-1) is overexpressed in various cancers and proliferating cells, but the functional significance remains unknown. In this study, we show that NGP-1 promotes G(1) to S phase transition of cells by enhancing CDK inhibitor p21(Cip-1/Waf1) expression through p53. In add...
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| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4571879/ https://ncbi.nlm.nih.gov/pubmed/26203195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.637280 |
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