Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G(1) to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21(Cip1/Waf1)

Nucleolar GTP-binding protein (NGP-1) is overexpressed in various cancers and proliferating cells, but the functional significance remains unknown. In this study, we show that NGP-1 promotes G(1) to S phase transition of cells by enhancing CDK inhibitor p21(Cip-1/Waf1) expression through p53. In add...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Datta, Debduti, Anbarasu, Kumaraswamy, Rajabather, Suryaraja, Priya, Rangasamy Sneha, Desai, Pavitra, Mahalingam, Sundarasamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571879/
https://ncbi.nlm.nih.gov/pubmed/26203195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.637280
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