The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis

The chromosome passenger complex (CPC) is a master regulator of mitosis. Inner centromere protein (INCENP) acts as a scaffold regulating CPC localization and activity. During early mitosis, the N-terminal region of INCENP forms a three-helix bundle with Survivin and Borealin, directing the CPC to th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Samejima, Kumiko, Platani, Melpomeni, Wolny, Marcin, Ogawa, Hiromi, Vargiu, Giulia, Knight, Peter J., Peckham, Michelle, Earnshaw, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571873/
https://ncbi.nlm.nih.gov/pubmed/26175154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645317
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