Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells

Heat shock protein (HSP) 72 in serum was decreased to a greater degree in patients with serious heat stroke than in those with mild heat stroke. Thus, increased levels of HSP72 appeared to correlate with a better outcome for the patient. Nevertheless, the function of HSP72 in the heat-induced hypoth...

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গ্রন্থ-পঞ্জীর বিবরন
প্রকাশিত:FEBS Open Bio
প্রধান লেখক: Lin, Kao-Chang, Lin, Hung-Jung, Chang, Ching-Ping, Lin, Mao-Tsun
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: Elsevier 2015
বিষয়গুলি:
Research article
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571539/
https://ncbi.nlm.nih.gov/pubmed/26448905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.09.001
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spelling pubmed-45715392015-10-07 Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells Lin, Kao-Chang Lin, Hung-Jung Chang, Ching-Ping Lin, Mao-Tsun FEBS Open Bio Research article Heat shock protein (HSP) 72 in serum was decreased to a greater degree in patients with serious heat stroke than in those with mild heat stroke. Thus, increased levels of HSP72 appeared to correlate with a better outcome for the patient. Nevertheless, the function of HSP72 in the heat-induced hypothalamic cell death has not been assessed. In this study, we found that increasing HSP72 levels with mild heat preconditioning or decreasing HSP72 levels with pSUPER plasmid expressing HSP72 small interfering RNA significantly attenuated or exacerbated heat-induced cell death in cultured primary hypothalamic cells, respectively. Our findings suggest that HSP72 plays a pivotal role in heat-induced cell death and may be associated with heat tolerance. Elsevier 2015-09-03 /pmc/articles/PMC4571539/ /pubmed/26448905 http://dx.doi.org/10.1016/j.fob.2015.09.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Research article
spellingShingle Research article
Lin, Kao-Chang
Lin, Hung-Jung
Chang, Ching-Ping
Lin, Mao-Tsun
Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells
description Heat shock protein (HSP) 72 in serum was decreased to a greater degree in patients with serious heat stroke than in those with mild heat stroke. Thus, increased levels of HSP72 appeared to correlate with a better outcome for the patient. Nevertheless, the function of HSP72 in the heat-induced hypothalamic cell death has not been assessed. In this study, we found that increasing HSP72 levels with mild heat preconditioning or decreasing HSP72 levels with pSUPER plasmid expressing HSP72 small interfering RNA significantly attenuated or exacerbated heat-induced cell death in cultured primary hypothalamic cells, respectively. Our findings suggest that HSP72 plays a pivotal role in heat-induced cell death and may be associated with heat tolerance.
author Lin, Kao-Chang
Lin, Hung-Jung
Chang, Ching-Ping
Lin, Mao-Tsun
author_facet Lin, Kao-Chang
Lin, Hung-Jung
Chang, Ching-Ping
Lin, Mao-Tsun
author_sort Lin, Kao-Chang
title Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells
title_short Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells
title_full Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells
title_fullStr Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells
title_full_unstemmed Decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells
title_sort decreasing or increasing heat shock protein 72 exacerbates or attenuates heat-induced cell death, respectively, in rat hypothalamic cells
publisher Elsevier
container_title FEBS Open Bio
publishDate 2015
url https://ncbi.nlm.nih.gov/pmc/articles/PMC4571539/
https://ncbi.nlm.nih.gov/pubmed/26448905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2015.09.001
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