Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation.

The cellular responses to ras and nuclear oncogenes were investigated in purified populations of rat Schwann cells. v-Ha-ras and SV40 large T cooperate to transform Schwann cells, inducing growth in soft agar and allowing proliferation in the absence of added mitogens. Expression of large T alone re...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Ridley, A J, Paterson, H F, Noble, M, Land, H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC457147/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3049071/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb02990.x
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