Release of Periplasmic Nucleotidase Induced by Human Antimicrobial Peptide in E. coli Causes Accumulation of the Immunomodulator Adenosine

Previous work by our group described that human β-defensin-2 induces accumulation of extracellular adenosine (Ado) in E. coli cultures through a non-lytic mechanism causing severe plasmolysis. Here, we investigate the presence of AMP as a direct precursor and the involvement of a bacterial enzyme in...

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Udgivet i:PLoS One
Main Authors: Estrela, Andreia Bergamo, Türck, Patrick, Stutz, Elaine, Abraham, Wolf-Rainer
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570785/
https://ncbi.nlm.nih.gov/pubmed/26371472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138033
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