The use of erythropoiesis-stimulating agents with ruxolitinib in patients with myelofibrosis in COMFORT-II: an open-label, phase 3 study assessing efficacy and safety of ruxolitinib versus best available therapy in the treatment of myelofibrosis

BACKGROUND: Anemia is considered a negative prognostic risk factor for survival in patients with myelofibrosis. Most patients with myelofibrosis are anemic, and 35–54 % present with anemia at diagnosis. Ruxolitinib, a potent inhibitor of Janus kinase (JAK) 1 and JAK2, was associated with an overall...

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Detalhes bibliográficos
Publicado no:Exp Hematol Oncol
Main Authors: McMullin, Mary Frances, Harrison, Claire N., Niederwieser, Dietger, Demuynck, Hilde, Jäkel, Nadja, Gopalakrishna, Prashanth, McQuitty, Mari, Stalbovskaya, Viktoriya, Recher, Christian, Theunissen, Koen, Gisslinger, Heinz, Kiladjian, Jean-Jacques, Al-Ali, Haifa-Kathrin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570722/
https://ncbi.nlm.nih.gov/pubmed/26380150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-015-0021-2
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