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Combined therapies that induce senescence and stabilize p53 block melanoma growth and prompt antitumor immune responses
We recently demonstrated that dual therapy combining AURKA and MDM2 antagonists is effective against melanoma in preclinical settings. Notably, besides inducing apoptosis, this regimen led to tumor senescence and stimulated the host's antitumor immune defenses. Treatments leveraging both cancer...
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| Veröffentlicht in: | Oncoimmunology |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570092/ https://ncbi.nlm.nih.gov/pubmed/26405565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1009299 |
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