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Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects

Witnessing pain and distress in others can cause psychological trauma and increase odds of developing PTSD in the future, on exposure to another stressful event. However, the underlying synaptic process remains unknown. Here we report that mice exposed to a conspecific receiving electrical footshock...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Ito, Wataru, Erisir, Alev, Morozov, Alexei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569943/
https://ncbi.nlm.nih.gov/pubmed/25865929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.100
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