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Which and How Many Patients Should Be Included in Randomised Controlled Trials to Demonstrate the Efficacy of Biologics in Primary Sjögren’s Syndrome?

OBJECTIVE: The goal of this study was to determine how the choice of the primary endpoint influenced sample size estimates in randomised controlled trials (RCTs) of treatments for primary Sjögren’s syndrome (pSS). METHODS: We reviewed all studies evaluating biotechnological therapies in pSS to ident...

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Publicat a:PLoS One
Autors principals: Devauchelle-Pensec, Valérie, Gottenberg, Jacques-Eric, Jousse-Joulin, Sandrine, Berthelot, Jean-Marie, Perdriger, Aleth, Hachulla, Eric, Hatron, Pierre Yves, Puechal, Xavier, Le Guern, Véronique, Sibilia, Jean, Chiche, Laurent, Goeb, Vincent, Vittecoq, Olivier, Larroche, Claire, Fauchais, Anne Laure, Hayem, Gilles, Morel, Jacques, Zarnitsky, Charles, Dubost, Jean Jacques, Dieudé, Philippe, Pers, Jacques Olivier, Cornec, Divi, Seror, Raphaele, Mariette, Xavier, Nowak, Emmanuel, Saraux, Alain
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569343/
https://ncbi.nlm.nih.gov/pubmed/26368934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133907
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