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Which and How Many Patients Should Be Included in Randomised Controlled Trials to Demonstrate the Efficacy of Biologics in Primary Sjögren’s Syndrome?
OBJECTIVE: The goal of this study was to determine how the choice of the primary endpoint influenced sample size estimates in randomised controlled trials (RCTs) of treatments for primary Sjögren’s syndrome (pSS). METHODS: We reviewed all studies evaluating biotechnological therapies in pSS to ident...
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發表在: | PLoS One |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
Public Library of Science
2015
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4569343/ https://ncbi.nlm.nih.gov/pubmed/26368934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133907 |
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