Which and How Many Patients Should Be Included in Randomised Controlled Trials to Demonstrate the Efficacy of Biologics in Primary Sjögren’s Syndrome?

OBJECTIVE: The goal of this study was to determine how the choice of the primary endpoint influenced sample size estimates in randomised controlled trials (RCTs) of treatments for primary Sjögren’s syndrome (pSS). METHODS: We reviewed all studies evaluating biotechnological therapies in pSS to ident...

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Published in:PLoS One
Main Authors: Devauchelle-Pensec, Valérie, Gottenberg, Jacques-Eric, Jousse-Joulin, Sandrine, Berthelot, Jean-Marie, Perdriger, Aleth, Hachulla, Eric, Hatron, Pierre Yves, Puechal, Xavier, Le Guern, Véronique, Sibilia, Jean, Chiche, Laurent, Goeb, Vincent, Vittecoq, Olivier, Larroche, Claire, Fauchais, Anne Laure, Hayem, Gilles, Morel, Jacques, Zarnitsky, Charles, Dubost, Jean Jacques, Dieudé, Philippe, Pers, Jacques Olivier, Cornec, Divi, Seror, Raphaele, Mariette, Xavier, Nowak, Emmanuel, Saraux, Alain
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569343/
https://ncbi.nlm.nih.gov/pubmed/26368934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133907
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