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Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence

The age-associated decline of immune responses causes high susceptibility to infections and reduced vaccine efficacy in the elderly. However, the mechanisms underlying age-related deficits are unclear. Here, we found that the expression and signaling of flagellin (FlaB)-dependent Toll-like receptor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Aging Cell
Hauptverfasser: Lim, Jae Sung, Nguyen, Kim Cuc Thi, Nguyen, Chung Truong, Jang, Ik-Soon, Han, Jung Min, Fabian, Claire, Lee, Shee Eun, Rhee, Joon Haeng, Cho, Kyung A
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568978/
https://ncbi.nlm.nih.gov/pubmed/26223660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12383
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