MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

Ependymal cells (ECs) form a barrier responsible for selective movement of fluids and molecules between the cerebrospinal fluid and the central nervous system. Here, we demonstrate that metabolic and barrier functions in ECs decline significantly during aging in mice. The longevity of these function...

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Publicat a:Aging Cell
Autors principals: Muthusamy, Nagendran, Sommerville, Laura J, Moeser, Adam J, Stumpo, Deborah J, Sannes, Philip, Adler, Kenneth, Blackshear, Perry J, Weimer, Jill M, Ghashghaei, H Troy
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568964/
https://ncbi.nlm.nih.gov/pubmed/26010231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12354
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