The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours

The tumour microenvironment is known to play an integral role in facilitating cancer progression at advanced stages, but its function in some pre-cancerous lesions remains elusive. We have used the (V600)(E)BRAF-driven mouse lung model that develop premalignant lesions to understand stroma–tumour in...

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Veröffentlicht in:EMBO Mol Med
Hauptverfasser: Kamata, Tamihiro, Jin, Hong, Giblett, Susan, Patel, Bipin, Patel, Falguni, Foster, Charles, Pritchard, Catrin
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568947/
https://ncbi.nlm.nih.gov/pubmed/26183450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404838
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