Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells

Age-related macular degeneration (AMD) is associated with dysfunction and death of retinal pigment epithelial (RPE) cells. Cell-based approaches using RPE-like cells derived from human pluripotent stem cells (hPSCs) are being developed for AMD treatment. However, most efficient RPE differentiation p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Maruotti, Julien, Sripathi, Srinivas R., Bharti, Kapil, Fuller, John, Wahlin, Karl J., Ranganathan, Vinod, Sluch, Valentin M., Berlinicke, Cynthia A., Davis, Janine, Kim, Catherine, Zhao, Lijun, Wan, Jun, Qian, Jiang, Corneo, Barbara, Temple, Sally, Dubey, Ramin, Olenyuk, Bogdan Z., Bhutto, Imran, Lutty, Gerard A., Zack, Donald J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568212/
https://ncbi.nlm.nih.gov/pubmed/26269569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422818112
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