PGC-1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization

Prolonged immobilization (IM) causes skeletal muscle atrophy characterized by mitochondrial deterioration and proteolysis. Muscle remobilization (RM) increases reactive oxygen species generation, proinflammatory cytokine expression, and oxidative stress, preventing muscle from quick recovery. Thus,...

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Опубликовано в: :FASEB J
Главные авторы: Kang, Chounghun, Goodman, Craig A., Hornberger, Troy A., Ji, Li Li
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2015
Предметы:
Research Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566942/
https://ncbi.nlm.nih.gov/pubmed/26178167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-266619
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