Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model

PURPOSE: We investigated the effects of GW559090, a novel, competitive, and high-affinity α4 integrin antagonist, in a murine model of dry eye. Through interaction with vascular cell adhesion molecule 1 (VCAM-1) and fibronectin α4β1 integrin is involved in leukocyte trafficking and activation. METHO...

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Foilsithe in:Invest Ophthalmol Vis Sci
Main Authors: Krauss, Achim H., Corrales, Rosa M., Pelegrino, Flavia S. A., Tukler-Henriksson, Johanna, Pflugfelder, Stephen C., de Paiva, Cintia S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Association for Research in Vision and Ophthalmology 2015
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566400/
https://ncbi.nlm.nih.gov/pubmed/26348638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-17249
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