Capsid display of a conserved human papillomavirus L2 peptide in the adenovirus 5 hexon protein: a candidate prophylactic hpv vaccine approach

BACKGROUND: Infection by any one of 15 high risk human papillomavirus (hrHPV) types causes most invasive cervical cancers. Their oncogenic genome is encapsidated by L1 (major) and L2 (minor) coat proteins. Current HPV prophylactic vaccines are composed of L1 virus-like particles (VLP) that elicit ty...

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Detalhes bibliográficos
Publicado no:Virol J
Main Authors: Wu, Wai-Hong, Alkutkar, Tanwee, Karanam, Balasubramanyan, Roden, Richard BS, Ketner, Gary, Ibeanu, Okechukwu A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566294/
https://ncbi.nlm.nih.gov/pubmed/26362430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-015-0364-7
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