Tuberous Sclerosis Complex 2 Loss Increases Lysophosphatidylcholine Synthesis in Lymphangioleiomyomatosis

Lymphangioleiomyomatosis (LAM) is a destructive lung disease affecting women. LAM is caused by mutations in the tuberous sclerosis complex (TSC) genes. The TSC protein complex inhibits the mechanistic/mammalian target of rapamycin complex 1 (mTORC1), which is a master regulator of cellular metabolis...

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Bibliografiske detaljer
Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Priolo, Carmen, Ricoult, Stéphane J. H., Khabibullin, Damir, Filippakis, Harilaos, Yu, Jane, Manning, Brendan D., Clish, Clary, Henske, Elizabeth P.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2015
Fag:
Rapid Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566115/
https://ncbi.nlm.nih.gov/pubmed/25780943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0379RC
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