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Impact of Subunit Composition on the Uptake of α-Crystallin by Lens and Retina

Misfolded protein aggregation, including cataract, cause a significant amount of blindness worldwide. α-Crystallin is reported to bind misfolded proteins and prevent their aggregation. We hypothesize that supplementing retina and lens with α-crystallin may help to delay disease onset. The purpose of...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mueller, Niklaus H., Fogueri, Uma, Pedler, Michelle G., Montana, Kameron, Petrash, J. Mark, Ammar, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565700/
https://ncbi.nlm.nih.gov/pubmed/26355842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137659
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