Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling

MuSK antibody-positive myasthenia gravis (MuSK-MG) accounts for 5 to 15% of autoimmune MG. MuSK and LRP4 are coreceptors for agrin in the signaling pathway that causes clustering of acetylcholine receptor (AChR). MuSK also anchors the acetylcholinesterase (AChE)/collagen Q (ColQ) complex to the syna...

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Publicado en:Sci Rep
Autores principales: Otsuka, Kenji, Ito, Mikako, Ohkawara, Bisei, Masuda, Akio, Kawakami, Yu, Sahashi, Ko, Nishida, Hiroshi, Mabuchi, Naoki, Takano, Akemi, Engel, Andrew G., Ohno, Kinji
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564764/
https://ncbi.nlm.nih.gov/pubmed/26355076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13928
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