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Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling
MuSK antibody-positive myasthenia gravis (MuSK-MG) accounts for 5 to 15% of autoimmune MG. MuSK and LRP4 are coreceptors for agrin in the signaling pathway that causes clustering of acetylcholine receptor (AChR). MuSK also anchors the acetylcholinesterase (AChE)/collagen Q (ColQ) complex to the syna...
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| Pubblicato in: | Sci Rep |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4564764/ https://ncbi.nlm.nih.gov/pubmed/26355076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13928 |
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